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In issue one of Noctua writer Andrew Henderson introduces to a universe where vampires, known as transhumans, co-exist with humans. Instead of running with a very supernatural setting the story takes place in the year 2051 after a virus has mutated 5% of Earth's population into transhumans.

The issue wastes no time in introducing the main characters and getting each of their stories goi ng. First we are introduced to the vigilante Noctua as he stops a group of blood traffickers. In the process he also saves a young girl and takes her into his care. The sequence not only does a great job at showing us how deadly Noctua can be but it gives us a sense of his reputation in the world.

One of the traffickers killed by Noctua turns out to be the son of Alucard Constans who aside from being a mob boss is also transhuman rights activist. The issue also introduces us to two detectives who work for the TRT; the Transhuman Relations Taskforce who are assigned to look into the blood traffickmore